Lazio rely on Luis Alberto and Sergei Milinkovic-Savic for their Europa League opener against Apollon Limassol.
It kicks off at the Stadio Olimpico at 17.55 UK time (16.55 GMT).
The Biancocelesti are still shaking off the disappointment of last season, as they had been minutes away from qualifying for the Champions League.
A last-gasp defeat to Inter meant they were bumped down to the Europa League and the baggage from that was still being felt at the start of the Serie A campaign with losses to Napoli and Juventus.
Simone Inzaghi has started to turn things around, back-to-back 1-0 victories over Frosinone and Empoli, but they still look a long way from confident.
Ciro Immobile, Wallace, Lucas Leiva and Senad Lulic are rested, while Luiz Felipe, Stefan Radu and Valon Berisha are out injured.
Summer signing Joaquin Correa still has to sit out a ban from last term, so Milinkovic-Savic and Milan Badelj run the midfield with Luis Alberto supporting Felipe Caicedo.
There’s a debut in goal for Belgian veteran Silvio Proto, resting Thomas Strakosha.
Apollon Limassol were in the Europa League last season too, where they had impressive draws with Olympique Lyonnais, Everton and Atalanta.
They already met Lazio in the 2013-14 Europa League group phase and again were tough to beat, drawing 0-0 in Nicosia and only narrowly defeated 2-1 at the Olimpico.
Among their stand-out names are Argentine Facundo Pereyra and Croatian Anton Maglica in attack.
Apollon also have an Italian player, Emilio Zelaya, who is on the bench.
Lazio: Proto; Bastos, Acerbi, Caceres; Basta, Murgia, Badelj, Milinkovic-Savic, Durmisi; Luis Alberto; Caicedo
Lazio bench: Guerrieri, Wallace, Marusic, Cataldi, Lucas Leiva, Lulic, Immobile
Apollon Limassol: Bruno Vale; Joao Pedro, Roberge, Yuste, Vasiliou; Kryiakou, Sacchetti; Schembri, Pereyra, Papoulis; Maglica
Apollon Limassol bench: Kissas, M Stylianou, Markovic, Bru, Soumah, Carayol, Zelaya, A Sardinero
Ref: Aghayev (AZE)