Milan try to end their four-game Atalanta curse in the Lombardy Derby, as Gonzalo Higuain and Suso face Papu Gomez and Musa Barrow.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
The Rossoneri scraped a 1-0 win on Thursday in the Europa League over Dudelange in Luxembourg and Higuain got the only goal.
Pipita has scored two and assisted one of Milan’s last three goals, so with Patrick Cutrone and Mattia Caldara injured, he again leads the line.
Suso and Hakan Calhanoglu complete the trident attack, moving Jack Bonaventura back to midfield.
Andrea Conti and Ivan Strinic are long-term absentees.
Atalanta have stuttered lately, as going out of the Europa League play-off with FC Copenhagen on penalties hit their confidence hard.
Papu Gomez shakes off a knock to start with ex-Milan man Mario Pasalic, but teenager Barrow is chosen rather than Duvan Zapata.
Milan haven’t beaten Atalanta in their last four meetings.
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Biglia, Bonaventura; Suso, Higuain, Calhanoglu
Atalanta: Gollini; Toloi, Palomino, Masiello; Castagne, De Roon, Freuler, Gosens; Pasalic; Gomez, Barrow