Napoli surprise everyone with their tactics, dropping Piotr Zielinski and Dries Mertens, as they welcome Mohamed Salah’s Champions League Finalists Liverpool.
It kicks off at the Stadio San Paolo at 20.00 UK time (19.00 GMT).
Follow all the build-up and action as it happens from this game and PSV Eindhoven-Inter on the LIVEBLOG.
Napoli surprise everyone with their tactics, dropping Piotr Zielinski and Dries Mertens, as they welcome Mohamed Salah’s Champions League Finalists Liverpool.
It kicks off at the Stadio San Paolo at 20.00 UK time (19.00 GMT).
Carlo Ancelotti continues his attempts to transform the original Maurizio Sarri 4-3-3, which until now has been a 4-4-2.
However, he causes a huge surprise with Nikola Maksimovic getting a very rare start in defence.
Director of sport Cristiano Giuntoli explained on Sky Sport Italia that it's a 4-4-1-1 when defending and a 3-5-2 in attack, with Mario Rui advancing on the left.
Piotr Zielinski, Dries Mertens and Elseid Hysaj are all dropped in favour of Fabian Ruiz, Arkadiusz Milik and Maksimoivc.
Although recent games have been positive, they are fresh from a defeat to Juventus in the top of the table showdown on Saturday, a game where Mario Rui was sent off for two bookable offences.
Liverpool reached the Champions League Final last season, eventually capitulating to Real Madrid, but have since strengthened by splashing out for Roma goalkeeper Alisson Becker.
They are the favourites to win the group, having beaten Paris Saint-Germain 3-2 in a thriller at Anfield, while they are also flying high in the Premier League.
Jurgen Klopp resists the temptation to rest any of his stars ahead of Sunday’s Premiership clash with Manchester City.
That means ex-Roma forward Salah starts with Roberto Firmino and Sadio Mane in the trident attack, while Virgil van Dijk is the rock in defence.
Adam Lallana is still out of action with a groin injury, while Naby Keita is chosen rather than Jordan Henderson in an all-attack side.
When these sides met in August’s pre-season friendly, Liverpool beat an experimental Napoli line-up 5-0.
Napoli: Ospina; Maksimovic, Koulibaly, Albiol, Mario Rui; Allan, Hamsik, Fabian, Callejon; Milik, Insigne
Napoli bench: Karnezis, Hysaj, Diawara, Rog, Zielinski, Mertens, Verdi
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Wijnaldum, Milner, Keita; Salah, Firmino, Mane
Liverpool bench: Mignolet, Fabinho, Lovren, Henderson, Sturridge, Moreno, Shaqiri