Juventus seek an 11th victory out of 11 with Juan Cuadrado and Cristiano Ronaldo against Genoa’s Capocannoniere Krzysztof Piatek.
It kicks off in Turin at 17.00 UK time (16.00 GMT).
The Bianconeri have a 100 per cent record so far this season, winning 10 out of 10 games in Serie A and the Champions League.
Paulo Dybala returned from international duty with Argentina suffering from a knee problem and is rested ahead of the Manchester United showdown.
Medhi Benatia and Alex Sandro are chosen ahead of Daniele Rugani, Giorgio Chiellini and Mattia De Sciglio, with Cuadrado completing the trident alongside Mandzukic and Ronaldo.
Genoa make their debut under ‘new’ Coach Ivan Juric, as this is his third different stint on the Grifone bench.
In fact, he had been fired in November 2017 to make way for Davide Ballardini, who got the sack last week.
He moves to a 3-5-2 formation with surprise pick of 20-year-old Cristian Romero at centre-back for his Serie A debut, Pedro Pereira and Darko Lazovic on the wings.
It’s an all-Brazilian midfield, but the big dangers are in attack with Christian Kouame and Capocannoniere Piatek, who has scored 14 goals in 10 games this season between club and country.
Juve are unbeaten in this fixture since a 1-0 result in January 1991, decided by Tomas Skuhravy, followed by 15 wins and three draws between Serie A and the Coppa Italia. Genoa haven’t even scored in their last six trips to Turin.
Juventus: Szczesny; Cancelo, Bonucci, Benatia, Alex Sandro; Bentancur, Pjanic, Matuidi; Cuadrado, Mandzukic, Cristiano Ronaldo
Juventus bench: Pinsoglio, Perin, De Sciglio, Chiellini, Dybala, Douglas Costa, Barzagli, Kean, Emre Can, Rugani, Bernardeschi
Genoa: Radu; Biraschi, Romero, Criscito; Pereira, Romulo, Sandro, Bessa, Lazovic; Piatek, Kouamé
Genoa bench: Marchetti, Gunter, Lopez, Lapadula, Mazzitelli, Rolon, Pandev, Lakicevic, Omeonga, Medeiros, Zukanovic, Hiljemark