Fiorentina try to maintain their perfect home record, but Cagliari lose Leonardo Pavoletti to fatherhood in a very special game.
It kicks off at 17.00 UK time (16.00 GMT), follow the build-up and action as it happens on the LIVEBLOG.
This match is serving as a commemoration of Davide Astori’s life, as these are the two clubs where he spent most of his playing career.
He had 179 appearances in the Cagliari jersey and 109 for Fiorentina until his death on March 4, aged just 31.
His parents and brothers are in attendance and received gifts from both sets of supporters.
The Viola are ready to make it five wins out of five at the Stadio Franchi, where they scored 12 goals this season and conceded only one.
Cagliari have to do without injured Diego Farias, Charalampos Lykogiannis and Ragnar Klavan, but there was a last-minute absentee too.
Leonardo Pavoletti has barely slept because his wife gave birth to son Giorgio in Sardinia overnight and he was keeping up to date with his family on events.
Therefore, Alberto Cerri leads the attack with Joao Pedro and Artur Ionita.
Fiorentina: Lafont; Milenkovic, Pezzella, Vitor Hugo, Biraghi; Edimilson, Veretout, Gerson; Chiesa, Simeone, Pjaca
Cagliari: Cragno; Farago, Ceppitelli, Pisacane, Padoin; Castro, Bradaric, Barella; Ionita; Joao Pedro, Cerri
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