Juventus rely on Cristiano Ronaldo and Paulo Dybala for the Champions League showdown with Paul Pogba’s Manchester United.
It kicks off at Old Trafford at 20.00 UK time (19.00 GMT).
Follow the build-up and action as it happens from this game and Roma-CSKA Moscow on the LIVEBLOG.
Juventus rely on Cristiano Ronaldo and Paulo Dybala for the Champions League showdown with Paul Pogba’s Manchester United.
It kicks off at Old Trafford at 20.00 UK time (19.00 GMT).
Follow the build-up and action as it happens from this game and Roma-CSKA Moscow on the LIVEBLOG.
The Bianconeri had a perfect start to the season with 10 wins out of 10 in all competition, but that run stalled with a surprise 1-1 draw against Genoa on Saturday.
To make matters worse, Mario Mandzukic has been ruled out for an injury, joining Sami Khedira and Leonardo Spinazzola on the touchline.
Emre Can was diagnosed with a thyroid nodule that may well require surgery, so it’s not clear when the former Liverpool man will be available.
It means Max Allegri had the option between a 4-4-2 formation or a 3-5-2, always keeping Cristiano Ronaldo and Dybala in attack.
Juan Cuadrado is the key, as he can move between the two systems, with Joao Cancelo and Alex Sandro also versatile wing-backs.
It’s a return to Old Trafford for Ronaldo, who scored 118 goals and provided 68 assists for Manchester United in 292 official matches from 2003 to 2009.
Pogba is also reunited with his former Juventus teammates and has been repeatedly linked with a move back to Turin, as his rapport with ex-Inter Coach Jose Mourinho is at an all-time low.
Manchester United have been struggling this season and are second in Group H after a 3-0 win away to Young Boys and 0-0 home draw with Valencia.
Juve are yet to concede in the Champions League, having conquered Valencia 2-0 despite that early Ronaldo card – which saw him suspended for the 3-0 home win over Young Boys, decided by a Dybala hat-trick.
Manchester United are missing Marouane Fellaini, Alexis Sanchez, Jesse Lingard, Phil Jones, Diogo Dalot and Scott McTominay, while Marcos Rojo and Antonio Valencia are not 100 per cent fit.
Matteo Darmian was linked with a move to Serie A over the summer, but the sometime Italy international is again on the United bench, while Victor Lindelof gets the nod at centre-back instead of Eric Bailly.
The dangers are all in attack with Pogba supporting Marcus Rashford, Anthony Martial and Romelu Lukaku.
The balance between these sides is absolute, with five wins each, two draws and 15 goals scored in their 12 previous meetings.
Manchester United: De Gea; Young, Lindelof, Smalling, Shaw; Mata, Matic, Pogba; Rashford, Lukaku, Martial
Manchester United bench: Romero, Bailly, Darmian, Fred, Andreas Pereira, Ander Herrera, Chong
Juventus: Szczesny; Cancelo, Bonucci, Chiellini, Alex Sandro; Bentancur, Pjanic, Matuidi; Cuadrado, Dybala, Ronaldo
Juventus bench: Perin, De Sciglio, Benatia, Douglas Costa, Barzagli, Kean, Bernardeschi
Ref: Mazic (SRB)