Lazio make numerous changes for their trip to Apollon Limassol, as they are qualified, but can still take the top Europa League spot.
It kicks off at 20.00 GMT, follow the build-up and action as it happens from this game and Milan v Dudelange on the LIVEBLOG.
Simone Inzaghi takes this opportunity to rotate the squad, as they have already qualified for the Round of 32 along with Eintracht Frankfurt.
As the Germans take on Olympique Marseille this evening and the final match is at the Olimpico, Lazio can still secure top spot in this group.
If Eintracht win and Lazio do not, then the Germans will lock down the leadership.
Lazio are without injured Lucas Leiva, but left Ciro Immobile, Milan Badelj and others at home.
Riza Durmisi, Joaquin Correa and Felipe Caicedo are given rare starts.
Apollon miss Carayol, Yuste and Bru, but opt for Faupala in attack.
Apollon Limassol: Bruno Vale; Joao Pedro, Ouedraogo, Soumah; Spoljaric, Sachetti; Sardinero, Markovic, Schembri; Faupala
Apollon bench: Kissas, Zelaya, Pereyra, Papoulis, Psychas, Vasiliou, Maglica
Lazio: Proto; Bastos, Acerbi, Luiz Felipe; Caceres, Murgia, Cataldi, Berisha, Durmisi; Correa; Caicedo
Lazio bench: Guerrieri, Alia, Rossi, Wallace, Lulic, Rezzi, Armini
Ref: Reinshreiber (ISR)