Sampdoria choose two trequartisti behind Fabio Quagliarella, as Bologna transform their attack to cause an upset.
It kicks off at Marassi at 19.30 GMT.
The Blucerchiati have hit a slump in recent weeks, not winning since the start of October.
Although the draw with Genoa did end their run of three straight defeats, Samp were fortunate to come away with a point from that Derby della Lanterna.
Edgar Barreto picked up a muscular injury in that game and is unavailable, so Dennis Praet, Karol Linetty and surprisingly England Under-21 international Ronaldo Vieira start in midfield.
Gianluca Caprari and Gaston Ramirez are given a double trequartista role behind Quagliarella.
Bologna are reportedly considering the axe for Coach Pippo Inzaghi, yet they have drawn four of the last five, which at least has given them some momentum.
Blerim Dzemaili and Sebastien De Maio are out of action, so Erik Pulgar takes over in the middle of the park.
Riccardo Orsolini and Rodrigo Palacio had been expected to start with Federico Santander, but instead it’s Ladislav Krejci and Diego Falcinelli in a 3-5-2.
Bologna are without a Serie A win at Marassi since a 3-2 thriller in March 1998, managing only three draws and eight defeats.
The odds aren’t good on changing that, as the Rossoblu haven’t won a single Serie A away fixture in 2018.
Sampdoria: Audero; Bereszynski, Andersen, Tonelli, Murru; Praet, Vieira, Linetty; Caprari, Ramirez; Quagliarella
Bologna: Skorupski; Calabresi, Danilo, Helander; Mattiello, Poli, Pulgar, Svanberg, Krejci; Santander, Falcinelli