Roma are forced into multiple changes due to an injury crisis and visit a Cagliari side who are still unbeaten on home turf this season.
It kicks off at the Sardegna Arena at 17.00 GMT.
You can follow the build-up and action as it happens from this game and Lazio v Sampdoria on the LIVEBLOG.
Roma are forced into multiple changes due to an injury crisis and visit a Cagliari side who are still unbeaten on home turf this season.
It kicks off at the Sardegna Arena at 17.00 GMT.
The Giallorossi are struggling with an unprecedented spate of injuries, missing Edin Dzeko, Stephan El Shaarawy, Daniele De Rossi, Ante Coric and Lorenzo Pellegrini.
Kostas Manolas also picked up a knock to the ankle in training, but is still risked from the start this evening.
Federico Fazio returns after missing last week’s thrilling 2-2 draw with Inter, while Patrik Schick again leads the line as the only real alternative to Dzeko.
Cengiz Under and Justin Kluivert form the young and exciting front three, with Alessandro Florenzi returning to his old right-back role.
Cagliari must do without suspended Italy international midfielder Nicolò Barella, plus injured Lucas Castro and Charalampos Lykogiannis.
Leonardo Pavoletti is the danger man in attack, as his aerial capability makes him a magnet for crosses into the box.
However, Pavoletti pulled out during the warm-up with a muscular issue and is replaced by Alberto Cerri in the starting XI.
The Sardinians are still unbeaten on home turf and sit five points clear of the relegation zone, but are without a Serie A victory since beating Chievo 2-1 on October 28.
The record of this fixture is surprisingly even, with 14 wins each and 10 draws on the island.
Roma are nonetheless unbeaten here since February 2012, a 4-2 loss with Luis Enrique on the bench.
Cagliari: Cragno; Srna, Ceppitelli, Klavan, Padoin; Faragò, Bradaric, Ionita; Joao Pedro; Farias, Cerri
Roma: Olsen; Florenzi, Manolas, Fazio, Kolarov; Nzonzi, Cristante; Under, Zaniolo, Kluivert; Schick
Ref: Mazzoleni