Milan are in crisis and Gennaro Gattuso makes more changes with Suso injured, as Frosinone are revitalised under new Coach Marco Baroni.
It kicks off at the revamped Stadio Benito Stirpe at 11.30 GMT.
Gattuso is hanging by a thread, as over the last few weeks, they crashed out of the Europa League to Olympiacos, failed to score in three consecutive Serie A games for the first time since 2001 and dropped behind Lazio to fifth place.
If they fire blanks again here, it’ll be their longest goalless streak since 1984, last finding the net against Parma on December 2.
There is a boost, as Franck Kessie and Tiemoue Bakayoko return from suspension, but Fabio Borini, Andrea Bertolacci, Lucas Biglia, Mattia Caldara and Giacomo Bonaventura are still side-lined.
More importantly, Suso is also now out of action with an inflammation, so Patrick Cutrone and Samu Castillejo flank Gonzalo Higuain, moving Hakan Calhanoglu into midfield again.
Cristian Zapata had started 10 competitive games in a row, but Mateo Musacchio makes his return from a knee injury with the first appearance since November 8.
Pipita is on his worst goalless run ever playing for an Italian club, but has very fond memories of Frosinone. It was against this side that his hat-trick for Napoli set the new all-time record for 36 goals in a single Serie A season.
Frosinone sacked Moreno Longo after managing only one victory all season, 3-0 away to SPAL, and brought in former Benevento boss Baroni.
He made a strong debut, scraping a draw away to fellow relegation strugglers Udinese thanks to a Camillo Ciano penalty, and wants to give the Canarini fans their first home success to cheer on.
Luca Paganini, Federico Dionisi and Emil Hallfredsson are all long-term absentees, while Joel Campbell and Rai Vloet are dropped again.
Ex-Inter forward Andrea Pinamonti pushes Daniel Ciofani to the bench.
The big surprise is 21-year-old Paolo Ghiglione in place of Francesco Zampano, as he makes his Serie A debut.
Ghiglione started out in the Milan youth academy and was sold to Genoa, where he is currently on loan to Frosinone.
Milan have won only one of their last seven Serie A fixtures away to newly-promoted sides. Apart from the 4-0 at SPAL in February, which was also their only clean sheet, they drew four and lost two.
Frosinone: Sportiello; Goldaniga, Ariaudo, Krajnc; Ghiglione, Chibsah, Maiello, Crisetig, Beghetto; Ciano, Pinamonti
Frosinone bench: Bardi, Molinaro, Gori, Ciofani, Soddimo, Zampano, Sammarco, Brighenti, Cassata, Salamon, Campbell, Besea
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Bakayoko, Calhanoglu; Castillejo, Higuain, Cutrone
Milan bench: Reina, Antonio Donnarumma, Mauri, Conti, Zapata, Montolivo, Abate, Simic, Halilovic, Laxalt, Tsadjout, Torrasi