Juventus make numerous changes for their Coppa Italia trip to Bologna, starting Douglas Costa and Moise Kean, while Roberto Soriano and Nicola Sansone debut.
The Round of 16 tie kicks off at the Stadio Dall’Ara at 19.45 GMT.
The winners will go through to face either Cagliari or Atalanta in the quarter-final later this month.
Max Allegri assured in his Press conference yesterday that he would field a full strength squad, but seems to have changed his mind.
Paulo Dybala, Cristiano Ronaldo and Giorgio Chiellini are among those rested, while Mario Mandzukic, Juan Cuadrado, Andrea Barzagli and Joao Cancelo are injured.
It gives teenager Moise Kean the chance to start with support from Federico Bernardeschi and Douglas Costa.
Medhi Benatia did get the nod in defence, as Daniele Rugani had a muscular issue in training this morning, but the Moroccan also pulled out in the warm-up and was replaced by Giorgio Chiellini.
Bologna are in the relegation zone of the Serie A table, but hope they can cause an upset in this one-off meeting with Coppa Italia holders Juventus.
Coach Pippo Inzaghi throws January buys Soriano and Sansone into the starting XI for their debuts after the loan move from Villarreal.
Federico Santander is injured and Andrea Poli suspended after he was caught on camera during the last round uttering a blasphemous phrase – the worst kind of swearing in the Italian language.
Mattia Destro is given a rare start with Sansone in attack.
Bologna: Da Costa; Calabresi, Danilo, Helander; Mattiello, Soriano, Pulgar, Svanberg, Dijks; Destro, Sansone
Juventus: Szczesny; De Sciglio, Chiellini, Bonucci, Spinazzola; Khedira, Pjanic, Emre Can; Bernardeschi, Kean, Douglas Costa
Ref: La Penna