Inter want to end their Sassuolo hoodoo with Joao Mario, Matteo Politano and Ivan Perisic supporting Mauro Icardi.
It kicks off at San Siro at 19.30 GMT.
The Nerazzurri have a surprisingly poor recent record against Sassuolo, losing seven of their last eight meetings.
It’s remarkable considering Inter beat the Neroverdi 7-0 on two different occasions.
This match will be played in an unusual atmosphere, because it is behind closed doors due to repeated incidents of racist abuse from the Inter fans.
The club, to their credit, are taking action to stamp out this unacceptable behaviour among their fanbase.
The stands will have 11,000 children from local schools this evening, hoping they’ll show the grown-ups how to cheer on a team.
They have also launched the ‘BUU’ initiative, transforming the ugly racist chant into an acronym for Brothers Universally United.
The players will have a patch on their jerseys this evening, with ‘No To Discrimination’ also written on it.
Coach Luciano Spalletti has a full squad to choose from, other than injured Keita Balde Diao, but Radja Nainggolan is left on the bench.
Politano and Perisic flank Icardi in a 4-3-3 formation, with Joao Mario and Matias Vecino in midfield.
Sassuolo make the trip without Marlon and Federico Di Francesco, while Gian Marco Ferrari, Claud Adjapong and Jeremie Boga and are not 100 per cent fit after lay-offs.
Kevin-Prince Boateng is the False 9 with support from Filip Djuricic and lifelong Inter fan Domenico Berardi.
Roberto De Zerbi’s men ended 2018 with a shocking 6-2 defeat to Atalanta and lost to Napoli in the Coppa Italia last week.
Inter: Handanovic; D'Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Brozovic, Joao Mario; Politano, Icardi, Perisic
Sassuolo: Consigli; Lirola, Magnani, Rogerio, Peluso; Duncan, Locatelli, Sensi; Berardi, Boateng, Djuricic