Inter start Lautaro Martinez again in place of demoted captain Mauro Icardi, as they host Fabio Quagliarella’s Europe-chasing Sampdoria.
It kicks off at San Siro at 17.00 GMT.
The Nerazzurri have been in crisis over the last few days, as although they managed to break the goal and win drought with Lautaro Martinez against Parma, then Il Toro scored again to beat Rapid Vienna in the Europa League, the situation has been dominated by Icardi.
He was stripped of his captaincy on Wednesday, then pulled out of the Europa League match and is still unavailable today, officially due to a knee inflammation.
Keita Balde Diao and Sime Vrsaljko are also out of action, with the new captain named as Samir Handanovic.
The 4-2-3-1 formation returns with Matteo Politano, Radja Nainggolan and Ivan Perisic behind Lautaro Martinez, while Roberto Gagliardini and Dalbert get rare starts.
Sampdoria miss Gaston Ramirez, Gianluca Caprari, Jakub Jankto and Edgar Barreto, while Omar Colley is only fit enough for the bench.
Gregoire Defrel gets the nod rather than Manolo Gabbiadini to partner Quagliarella, with Riccardo Saponara in the trequartista role.
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar, Dalbert; Gagliardini, Brozovic; Politano, Nainggolan, Perisic; Lautaro Martinez
Sampdoria: Audero; Bereszynski, Andersen, Tonelli, Murru; Praet, Ekdal, Linetty; Saponara; Quagliarella, Defrel