Empoli have Ismael Bennacer back to support Diego Farias and Francesco Caputo, while Parma still cannot count on Alessandro Bastoni.
It kicks off at 14.00 GMT at the Stadio Castellani.
The Tuscans are in dire need of a boost after their 3-0 defeat to Milan and continue to hover just above the relegation zone.
Luca Antonelli and Levan Mchedlidze are out of action, but Ismael Bennacer and Domenico Maietta are back in the squad.
Parma welcome back Bastoni from injury, but he is only fit for the bench, while Antonino Barillà also returns after he was dropped against Napoli.
This means Massimo Gobbi is adapted at centre-back with Riccardo Gagliolo also in defence.
Gervinho and Roberto Inglese are this time flanked by Luca Siligardi rather than Jonathan Biabiany.
Empoli: Dragowski; Veseli, Silvestre, Dell'Orco; Di Lorenzo, Krunic, Bennacer, Acquah, Pasqual; Farias, Caputo
Empoli bench: Provedel, Perucchini, Brighi, Pajac, Traore, La Gumina, Maietta, Capezzi, Rasmussen, Oberlin, Nikolaou, Salih Ucan
Parma: Sepe; Iacoponi, Bruno Alves, Gobbi, Gagliolo; Kucka, Rigoni, Barillà; Gervinho, Inglese, Siligardi
Parma bench: Frattali, Dimarco, Diakhate, Schiappacasse, Sierralta, Machin, Gazzola, Dezi, Davordzie, Biabiany, Sprocati, Bastoni
Ref: Di Bello