Napoli look to Lorenzo Insigne and Arkadiusz Milik with a completely new central defensive partnership for their Europa League trip to RB Salzburg.
It kicks off at 17.55 GMT and follows on from the 3-0 first leg victory at the Stadio San Paolo.
Carlo Ancelotti has to focus on the Europa League now, as it is the only available objective remaining after crashing out of the Coppa Italia and falling 18 points adrift of Serie A leaders Juventus.
To make matters worse, Kalidou Koulibaly and Nikola Maksimovic are suspended for this match, with Raul Albiol injured, so Vlad Chiriches and Sebastiano Luperto are the all-new centre-back pairing.
There had been some doubts over Fabian Ruiz’s fitness, but the Spanish midfielder makes it.
RB Salzburg are forced to do without suspended midfielder Xaver Schlager, so exciting Hungarian teen Dominik Szoboszlai and Enock Mwepu step into the starting XI with Takumi Minamino fit again.
RB Salzburg: Walke; Lainer, Onguene, Ramalho, Ulmer; Mwepu, Samassekou, Wolf, Szoboszlai; Minamino, Dabbur
Salzburg bench: Stankovic, Vallci, Daka, Gulbrandsen, Leitgeb, Haland, Todorovic
Napoli: Meret; Hysaj, Chiriches, Luperto, Mario Rui; Callejon, Allan, Fabian Ruiz, Zielinski; Milik, Insigne
Napoli bench: Ospina, Malcuit, Ghoulam, Diawara, Younes, Verdi, Mertens
Ref: Cerri Grande (ESP)