Juventus must do without Cristiano Ronaldo, but drop Moise Kean and Leonardo Bonucci as they host relegation-threatened Empoli.
It kicks off in Turin at 17.00 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
Ronaldo returned from international duty in Portugal with a thigh injury and is at risk for the first leg of the Champions League quarter-final against Ajax next month.
As Kean started both Italy matches against Finland and Liechtenstein, scoring in each cap, the 19-year-old is rested in favour of a trident attack with Mario Mandzukic, Paulo Dybala and Federico Bernardeschi.
That was the plan, but Dybala pulled out in the warm-up with a thigh issue, so Rodrigo Bentancur steps in.
Bonucci is also rested in favour of Daniele Rugani, while Douglas Costa, Juan Cuadrado and Andrea Barzagli are out of action.
Juve went into the break for international duty with their first Serie A defeat of the season, losing 2-0 to Genoa.
Empoli have defender Matias Silvestre suspended, with Antonino La Gumina, Levan Mchedlidze, Kevin Diks and Jacob Rasmussen unavailable.
The Tuscans have been revitalised by the return of Coach Aurelio Andreazzoli, replacing sacked Beppe Iachini, and earned a precious 2-1 victory over Frosinone on his comeback.
Rade Krunic pulls the midfield strings, with Diego Farias and Francesco ‘Ciccio’ Caputo upfront.
Juventus have won each of their last seven Serie A meetings with Empoli, home and away, conceding only two goals.
Juventus: Szczesny; Cancelo, Rugani, Chiellini, Alex Sandro; Emre Can, Pjanic, Bentancur, Matuidi; Bernardeschi, Mandzukic
Juventus bench: Perin, Pinsoglio, De Sciglio, Caceres, Bonucci, Spinazzola, Nicolussi Caviglia, Kean
Empoli: Dragowski; Veseli, Maietta, Dell’Orco; Di Lorenzo, Traoré, Bennacer, Krunic, Pajac; Farias, Caputo
Empoli bench: Provedel, Perucchini, Brighi, Antonelli, Acquah, Pasqual, Capezzi, Oberlin, Nikolaou, Ucan
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