Atalanta know that a victory would move them to within a point of Milan and fourth place, but Bologna need a result to escape the relegation zone.
It kicks off in Bergamo at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from this game and Sassuolo-Chievo on the LIVEBLOG.
Atalanta know that a victory would move them to within a point of Milan and fourth place, but Bologna need a result to escape the relegation zone.
It kicks off in Bergamo at 20.00 UK time (19.00 GMT).
This is a massive opportunity for Gian Piero Gasperini’s men, because so far in the midweek round Milan have been held to a draw by Udinese, Roma stalled with Fiorentina and Lazio lost to SPAL.
It means a win here would put Atalanta alone in fifth place, three points clear of the chasing pack, and only one point behind a Milan side who face Juventus this weekend.
Rafael Toloi is out injured, but Josip Ilicic returns to the starting XI with Duvan Zapata and Papu Gomez.
Bologna are highly-motivated too, as last week they scrambled out of the relegation zone for the first time in four months thanks to a last-gasp win over Sassuolo.
Mattia Destro celebrated that goal so much that he injured himself, but Federico Santander returns to the bench after a month out with a dislocated shoulder.
Federico Mattiello is also out of action, with Erick Pulgar returning to the starting XI, but there are numerous changes with Arturo Calabresi, Ladislav Krejci, Adam Nagy and Diego Falcinelli coming in.
Empoli beat Napoli yesterday, so Bologna need at least a point to get back out of the bottom three.
Sinisa Mihajlovic’s Rossoblu have won three games on the bounce and a fourth would be the club’s best run since May 1967.
Bologna have won only one of their last 27 Serie A trips to Atalanta, losing 15 and drawing 11. That includes four consecutive defeats, while they have lost their last six top flight encounters with Atalanta, home and away.
Atalanta: Gollini; Mancini, Palomino, Masiello; Hateboer, De Roon, Freuler, Gosens; Gomez; Ilicic, Duvan Zapata
Atalanta bench: Berisha, Rossi, Reca, Piccoli, Djimsiti, Castagne, Pessina, Ibanez, Kulusevski, Pasalic, Barrow
Bologna: Skorupski; Calabresi, Gonzalez, Lyanco, Krejci; Donsah, Pulgar, Nagy; Orsolini, Falcinelli, Sansone
Bologna bench: Da Costa, Paz, Santander, Mbaye, Poli, Helander, Valencia, Soriano, Danilo, Palacio, Dzemaili, Dijks
Ref: Rocchi