Napoli have Lorenzo Insigne back on the bench, but look to Dries Mertens, Arkadiusz Milik and Faouzi Ghoulam against a reshuffled Genoa defence.
It kicks off at the Stadio San Paolo at 19.30 UK time (18.30 GMT).
The Partenopei know that if they lose this evening, Juventus will mathematically be crowned Champions of Italy without even stepping on to the pitch.
The Bianconeri’s 2-1 win over Milan last night means Napoli need a point, because otherwise they can’t overtake them in the table, having an inferior head-to-head record.
Carlo Ancelotti’s focus is also on the upcoming Europa League quarter-final against Arsenal, so Insigne only back on the bench after a muscular injury.
Simone Verdi had been expected to start, but will not be risked after a muscular twinge in training today, while Raul Albiol and Amadou Diawara are injured.
Faouzi Ghoulam makes his comeback after three weeks out injured, while Orestis Karnezis gets a rare run-out in goal.
Genoa don’t seem to do things by halves, as they were capable of beating Lazio and Juventus, yet lost 4-0 to Inter midweek.
Cristian Romero was sent off in that match and is therefore suspended along with fellow defender Ervin Zukanovic, so Gunter steps in and Domenico Criscito moves to a centre-back role.
Former Napoli striker Goran Pandev is partnered by potential future Partenopei forward Christian Kouame.
Napoli: Karnezis; Hysaj, Maksimovic, Koulibaly, Ghoulam; Callejon, Allan, Fabian, Zielinski; Mertens, Milik
Genoa: Radu; Biraschi, Gunter, Criscito, Pereira; Sturaro, Veloso, Bessa, Lazovic; Kouame, Pandev