Vincenzo Montella makes his debut on the Fiorentina bench by moving to a 3-5-2 formation against Bologna with Luis Muriel and Giovanni Simeone together.
It kicks off at 14.00 UK time (13.00 GMT).
The Viola are crawling towards the end of this season after a series of poor results, culminating in the 1-0 home defeat to Frosinone.
Coach Stefano Pioli resigned after that game in protest at the statement from the club that criticised his professionalism, so Montella was brought in.
The tactician returns to the Viola bench after several years away and makes changes, moving to a 3-5-2 formation with Federico Chiesa wide right, Muriel and Simeone upfront.
Marko Pjaca is out injured for the rest of the season, but Marco Benassi is benched.
Bologna need points to keep clear of the relegation zone, especially after SPAL’s surprise 2-1 win over Juventus on Saturday.
Mattia Destro, Filip Helander and Federico Mattiello miss out, while Federico Santander is still not quite at 100 per cent after his lay-off for a dislocated shoulder.
Rodrigo Palacio leads the attack with support from Nicola Sansone, Roberto Soriano and Riccardo Orsolini.
Fiorentina: Lafont; Milenkovic, Pezzella, Ceccherini; Chiesa, Dabo, Veretout, Gerson, Biraghi; Muriel, Simeone
Bologna: Skorupski; Mbaye, Danilo, Lyanco, Dijks; Poli, Pulgar, Soriano; Orsolini, Palacio, Sansone