Juventus need a point to secure their eighth consecutive Scudetto, but old rivals Fiorentina will do all they can to extend a nightmare week.
It kicks off at the Allianz Juventus Stadium at 17.00 UK time (16.00 GMT).
The Bianconeri were in this same position a week ago, ready to get the title party started a record six rounds early, but allowed SPAL to come back and beat them 2-1.
That was followed by a 2-1 home defeat at the hands of Ajax that knocked them out of the Champions League at the quarter-final stage.
While an eighth Serie A title in a row is a remarkable feat, it is a fact that Juventus have won less this season than in recent campaigns, managing only the Italian Super Cup.
They went out in the Coppa Italia quarter-finals to Atalanta and despite having Cristiano Ronaldo, were deeply disappointing in Europe yet again.
Max Allegri said he’ll remain on the Juventus bench, although the fans might be turning on him and the club, so even if the Scudetto is clinched today, there won’t be much of a party atmosphere in Turin.
The injury list is extensive, missing Paulo Dybala, Mario Mandzukic, Sami Khedira, Giorgio Chiellini, Douglas Costa, Mattia Perin and Martin Caceres.
Juan Cuadrado therefore completes the trident attack with Federico Bernardeschi, as Cristiano Ronaldo is moved into a centre-forward role, leaving teenage sensation Moise Kean on the bench.
Fiorentina aren’t in a much better mood, as Vincenzo Montella debuted with a dismal 0-0 home draw against Bologna after replacing Stefano Pioli.
Marko Pjaca is out for the season and will therefore return to Juventus after his ill-fated loan spell.
Federico Chiesa has been linked with a move away in the summer, with Juventus among those interested, and he leads the way with Giovanni Simeone and Kevin Mirallas.
Luis Muriel is rested, as Fiorentina will face Atalanta in Thursday’s absolutely crucial Coppa Italia semi-final.
Goals are a real problem, as the Tuscans fired blanks in their last two games and a third would be their longest negative streak since February 2012.
Since the Juventus Stadium opened, the Viola have lost all seven Serie A visits here, conceding 14 goals.
Juventus: Szczesny; Cancelo, Bonucci, Rugani, Alex Sandro; Emre Can, Pjanic, Matuidi; Cuadrado, Ronaldo, Bernardeschi
Fiorentina: Lafont; Milenkovic, Ceccherini, Pezzella, Hancko; Benassi, Veretout, Dabo; Mirallas, Simeone, Chiesa