Atalanta are forced to reshuffle without Papu Gomez and have their defence against Genoa, so Mario Pasalic and Hans Hateboer step in.
It kicks off at the Mapei Stadium at 14.00 UK time (13.00 GMT), a change of venue because Atalanta’s Stadio Azzurri d’Italia is undergoing restructuring work.
The Orobici currently sit three points clear of Milan and Roma in fourth place, which would qualify them for the group stage of the Champions League.
In fact, being only one point behind Inter, a victory today would temporarily put them in third.
However, Coach Gian Piero Gasperini has to completely revamp his side, as captain Papu Gomez is suspended along with Andrea Masiello and Gianluca Mancini.
Add Rafael Toloi out injured and there is a shortage of centre-backs, so Hateboer is being repurposed as part of the three-man defence.
Mario Pasalic comes in to the trequartista role, allowing Josip Ilicic to support Capocannoniere candidate Duvan Zapata.
Genoa are in dire need of precious points too, because they are only four points clear of the relegation zone with three rounds remaining.
Their form has not improved despite Cesare Prandelli being their third Coach of the season, but they are fresh from a dramatic 1-1 draw with Roma.
It would’ve been a victory, but Antonio Sanabria saw his stoppage-time penalty saved.
Unsurprisingly, Sanabria is back on the bench in favour of Gianluca Lapadula and Christian Kouame, while Darko Lazovic joins Stefano Sturaro, Luca Mazzitelli, Oscar Hiljemark and Andrea Favilli on the treatment table.
This is a special game for both tacticians, as while Gasperini had two very successful spells on the Genoa bench, Prandelli started out in the Atalanta youth academy as a Coach and was their caretaker manager in 1993-94.
There have been 35 goals in the last 10 Serie A meetings between these teams. Their last draw was 2-2 at Marassi in January 2015, followed by five Atalanta wins and three for Genoa.
Atalanta: Gollini; Hateboer, Djimsiti, Palomino; Castagne, De Roon, Freuler, Gosens; Pasalic; Ilicic, Duvan Zapata
Atalanta bench: Berisha, Rossi, Reca, Piccoli, Pessina, Ibanez, Colpani, Del Prato, Barrow
Genoa: Radu; Biraschi, Romero, Zukanovic, Criscito; Lerager, Radovanovic, Veloso; Bessa, Lapadula, Kouame
Genoa bench: Marchetti, Jandrei, Gunter, Sanabria, Pezzella, Rolon, Pandev, Dalmonte, Pedro Pereira, Lakicevic, Schafer