Fabio Quagliarella seeks the Capocannoniere title with Sampdoria, who host a revamped Juventus including Moise Kean and Matheus Pereira.
It kicks off at 17.00 UK time (16.00 GMT), you can follow the build-up and action as it happens from all EIGHT Serie A games on the LIVEBLOG.
The Bianconeri sealed their eighth consecutive Scudetto several weeks ago, but this represents the final match for Coach Max Allegri and defender Andrea Barzagli.
Cristiano Ronaldo has been left behind along with numerous other Juve players, including Douglas Costa, Sami Khedira, Mario Mandzukic, Alex Sandro, Mattia Perin and the suspended pair Federico Bernardeschi and Blaise Matuidi.
Kean leads the attack with Paulo Dybala, while Juan Cuadrado and young Brazilian Matheus Pereira take the flanks.
Carlo Pinsoglio is given his season debut in goal.
Sampdoria have one thing to play for still, as Quagliarella is currently the Capocannoniere on 26 Serie A goals, a personal best.
The veteran can clinch that crown at the age of 36.
Nicola Murru is out injured, but scouts from Premier League clubs as well as Juve are watching Dennis Praet and Karol Linetty.
Juve have lost only one of their last 11 Serie A meetings with Sampdoria, 3-2 here in November 2017, along with a draw and nine victories.
Sampdoria: Rafael; Sala, Ferrari, Colley, Bereszynski; Praet, Barreto, Linetty; Ramirez; Defrel, Quagliarella
Juventus: Pinsoglio; Caceres, Rugani, Chiellini, De Sciglio; Cuadrado, Bentancur, Emre Can; Dybala, Kean, Pereira