Inter will be without Diego Godin, Alessandro Bastoni, Kwadwo Asamoah, Matias Vecino, Valentino Lazaro and Lautaro Martinez against Tottenham Hotspur.
Godin, Lazaro and Bastoni are injured, while Asamoah, Vecino and Martinez have only just begun preseason training after extended summer breaks.
Radja Nainggolan is not included as he completes a move back to Cagliari and there is no change over Mauro Icardi, who remains in the wilderness.
There is also no place for striker Facundo Colidio, who is of interest to Leeds United and Newcastle United, although Joao Mario does travel to Tottenham, amidst Brighton and Hove Albion and Monaco speculation.
The International Champions Cup finale kicks off tomorrow afternoon.
Inter squad to face Tottenham: Handanovic, Padelli, Berni; De Vrij, Skriniar, Ranocchia, D’Ambrosio, Dalbert, Dimarco, Pirola: Brozovic, Sensi, Valero, Joao Mario, Gagliardini, Candreva, Agoume, Barella; Politano, Perisic, Longo, Esposito, Puscas
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