Mario Balotelli makes his Brescia debut and is in the starting XI against Champions of Italy Juventus, who look to Paulo Dybala and Adrien Rabiot.
It kicks off at the Stadio Rigamonti at 20.00 UK time (19.00 GMT).
You can follow all the action as it happens from this game and Verona–Udinese on the LIVEBLOG.
Mario Balotelli makes his Brescia debut and is in the starting XI against Champions of Italy Juventus, who look to Paulo Dybala and Adrien Rabiot.
It kicks off at the Stadio Rigamonti at 20.00 UK time (19.00 GMT).
You can follow all the action as it happens from this game and Verona-Udinese on the LIVEBLOG.
Balotelli arrived as a free agent from Olympique Marseille and joined his hometown club, but had to sit out a four-match ban left over from his Ligue 1 experience.
That has now expired and the Italy international makes his return to Serie A after 1,228 days, since Milan hosted Roma in May 2016.
SuperMario has a decent record against Juventus, as in two Serie A starts against the Old Lady he scored (April 2009 for Inter) and provided an assist (April 2016 for Milan).
He is partnered by Alfredo Donnarumma, who has scored three goals in his first four career Serie A appearances, as Ernesto Torregrossa, Emanuele Ndoj, Mattia Viviani, Bruno Martella and Giangiacomo Magnani are injured.
Brescia are the first promoted club to achieve six points in the opening four Serie A rounds since Livorno (seven) and Verona (six) in 2013-14.
Juventus are still adapting to Maurizio Sarri’s tactics, especially with Douglas Costa, Mattia De Sciglio, Mark Pjaca, Mattia Perin and captain Giorgio Chiellini injured.
Cristiano Ronaldo is rested and hasn’t even made the trip to Brescia for this midweek round, while Mario Mandzukic is still in negotiations for a potential transfer to Qatar.
It means Dybala and Gonzalo Higuain are given the chance to start together with Aaron Ramsey, who scored on his full debut against Hellas Verona at the weekend, the trequartista in a new 4-3-1-2 formation.
It’s not entirely new, of course, as Sarri already used this system before developing the 4-3-3 at Napoli and Chelsea.
The big change is Rabiot getting his first start in midfield, allowing Blaise Matuidi to rest.
Juve have won only three of their last 11 Serie A trips to Brescia, drawing six and losing two. The Bianconeri have not lost away to a newly-promoted side since May 2013 at Sampdoria, managing 14 wins and four draws.
Brescia: Joronen; Sabelli, Cistana, Chancellor, Mateju; Bisoli, Tonali, Dessena; Romulo; Balotelli, A Donnarumma
Brescia bench: Alfonso, Gastaldello, Spalek, Zmrhal, Aye, Matri, Morossini, Martella
Juventus: Szczesny; Danilo, Bonucci, De Ligt, Alex Sandro; Khedira, Pjanic, Rabiot; Ramsey; Higuain, Dybala
Juventus bench: Pinsoglio, Buffon, Matuidi, Cuadrado, Emre Can, Rugani, Demiral, Bentancur, Bernardeschi
Ref: Pasqua