Roma are seeking their fourth consecutive victory in all competition and host the endlessly-entertaining Atalanta, with Edin Dzeko and Chris Smalling against Papu Gomez and Josip Ilicic.
It kicks off at the Stadio Olimpico at 18.00 UK time (17.00 GMT).
You can follow the build-up and action as it happens from all SEVEN of today’s Serie A games on the LIVEBLOG.
The Giallorossi have found their feet under new Coach Paulo Fonseca and won three on the row between Serie A and the Europa League, including four goals past Sassuolo and Istanbul Basaksehir.
Dzeko leads the way again with support from Lorenzo Pellegrini and Nicolò Zaniolo, but Henrikh Mkhitaryan is rested in favour of Alessandro Florenzi in a more advanced role.
Ex-Atalanta midfielder Bryan Cristante is joined by Jordan Veretout.
Another former Atalanta man, defender Gianluca Mancini, is suspended, so former Manchester United defender Chris Smalling makes his debut, with Davide Zappacosta, Cengiz Under and Diego Perotti injured.
Atalanta surprised everyone last season by taking third place, but their Champions League debut did not go as planned, losing 4-0 at Dinamo Zagreb.
They fought back from 2-0 down for a dramatic 2-2 draw with Fiorentina on Sunday, with Timothy Castagne marking his full comeback from knee surgery with a last-gasp volley.
Josip Ilicic and Papu Gomez were rested from the starting XI of that game, but return this evening in a surprise twist, as Duvan Zapata is only on the bench.
Luis Muriel didn’t make the trip after suffering from tonsillitis, so Duvan Zapata’s start had seemed a guarantee, but instead Ruslan Malinovskyi takes the trequartista role, moving Papu further up.
There is a debut in defence for former Palermo and Sevilla centre-back Simon Kjaer.
Last season, both Serie A meetings between these clubs ended 3-3, so entertainment is bound to be on the cards.
Atalanta are unbeaten in their last five Serie A trips to the Olimpico, winning three and drawing two.
Home and away, the Orobici have lost only one of their most recent nine top-flight encounters with the Giallorossi.
Roma: Pau Lopez; Spinazzola, Smalling, Fazio, Kolarov; Cristante, Veretout; Florenzi, Pellegrini, Zaniolo; Dzeko
Roma bench: Fuzato, Mirante, Juan Jesus, Santon, Kalinic, Pastore, Diawara, Antonucci, Mkhitaryan, Kluivert
Atalanta: Gollini; Toloi, Kjaer, Palomino; Hateboer, Freuler, De Roon, Castagne; Malinovskyi; Gomez, Ilicic
Atalanta bench: Rossi, Sportiello, Masiello, Gosens, Arana, Djimsiti, Ibanez, Pasalic, Duvan Zapata, Barrow
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/