Dries Mertens partners Fernando Llorente and Nikola Maksimovic passes a fitness test, as Napoli take on Mario Balotelli’s Brescia.
It kicks off at 11.30 UK time (10.30 GMT).
Carlo Ancelotti has to balance squad rotation ahead of a Champions League trip to Genk with the need to keep their Serie A campaign on track after a surprise 1-0 home defeat to Cagliari.
Kalidou Koulibaly begins his two-match Serie A ban after a red card in that game for insulting the referee, while Maksimovic had been in doubt with a muscular issue, but is passed fit to start.
Mertens and Llorente form the new partnership upfront after the Spaniard bagged a brace in the 4-1 victory away to Lecce.
Alex Meret, Lorenzo Insigne, Hirving Lozano and Arkadiusz Milik are rested, with Piotr Zielinski moving out wide on the left.
Brescia continue to miss long-term absentees Ernesto Torregrossa, Emanuele Ndoj and Giangiacomo Magnani.
Balotelli had been dealing with a slight neck sprain, but is ready to start alongside Neapolitan Alfredo Donnarumma.
Nicolas Spalek is the trequartista, with Romulo rested after an exhausting midweek display against Juventus.
Napoli: Ospina; Di Lorenzo, Manolas, Maksimovic, Ghoulam; Callejon, Allan, Fabian, Zielinski; Mertens, Llorente
Napoli bench: Meret, Karnezis, Malcuit, Mario Rui, Lozano, Elmas, Luperto, Hysaj, Insigne, Younes, Gaetano, Milik
Brescia: Joronen; Sabelli, Cistana, Chancellor, Martella; Bisoli, Tonali, Dessena; Spalek; Balotelli, A Donnarumma
Brescia bench: Alfonso, Mateju, Gastaldello, Zmrhal, Aye, Matri, Morosini, Romulo
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