Juventus have Alex Sandro back, with Federico Bernardeschi, Gonzalo Higuain and Cristiano Ronaldo in a 4-3-3 against Bayer Leverkusen.
It kicks off at 20.00 UK time (19.00 GMT) at the Allianz Juventus Stadium in Turin.
You can follow all the action as it happens from that game and Atalanta-Shakhtar Donetsk on the LIVEBLOG.
The Bianconeri fumbled a 2-0 lead to draw 2-2 with Atletico Madrid in their opening Champions League group game, confirming their tendency to concede goals from set-play situations.
There is a shortage of full-backs and wide men, as Danilo, Mattia De Sciglio and Douglas Costa are injured, but Alex Sandro returns after spending time in Brazil on compassionate leave.
Juan Cuadrado steps into right-back, with Matthijs de Ligt in for injured captain Giorgio Chiellini.
After several games using the 4-3-1-2 formation with Aaron Ramsey as trequartista, Maurizio Sarri suddenly lurches back to a 4-3-3 with Bernardeschi, Higuain and Cristiano Ronaldo, as Paulo Dybala also drops to the bench.
Bayer Leverkusen are without injured Bellarabi and Leon Bailey, but Wendell returns at left-back.
They move to a more defensive 4-4-2 with Keren Demirbay on the flank, Kevin Volland and Lucas Alario upfront.
Juventus: Szczesny; Cuadrado, Bonucci, De Ligt, Alex Sandro; Khedira, Pjanic, Matuidi; Bernardeschi, Higuain, Cristiano Ronaldo
Juventus bench: Buffon, Ramsey, Dybala, Rugani, Rabiot, Demiral, Bentancur
Bayer Leverkusen: Hradecky; L Bender, Tah, S Bender, Wendell; Havertz, Aranguiz, Baumgartlinger, Demirbay; Volland, Alario
Bayer Leverkusen bench: Ozcan, Dragovic, Paulinho, Amiri, Diaby, Sinkgraven, Weiser
Ref: Collum (SCO)
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