It is already a must-win game for Lazio in the Europa League against Stade Rennais, so Ciro Immobile and Felipe Caicedo lead the attack against ex-Milan striker M’Baye Niang.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens from this game and Wolfsberger-Roma on the LIVEBLOG.
The pressure is on Simone Inzaghi after the deeply disappointing 2-1 defeat away to CFR Cluj, a game Lazio had been leading with great confidence until the now traditional late collapse in focus and energy levels.
Inzaghi keeps squad rotation to a minimum, as Joaquin Correa is out injured and Adam Marusic suspended, so Caicedo partners Immobile in attack, with Manuel Lazzari and Senad Lulic on the wings, preferred to Jony Rodriguez.
Danilo Cataldi and Valon Berisha get the nod in midfield, resting Sergej Milinkovic-Savic and Luis Alberto, while Denis Vavro gets his chance in defence.
Rennes qualified for the Europa League after beating Paris Saint-Germain on penalties in the French Cup Final.
They also did well in this tournament last season, going out in the Round of 16 to eventual runners-up Arsenal, despite winning the home leg 3-1.
Stade Rennais drew the opening match of this group 1-1 at home to Celtic, with both goals coming from the penalty spot.
There are some familiar faces in the side, including former Milan striker M’Baye Niang and ex-Roma midfielder Clement Grenier.
Raphinha will be known to anyone following the transfer speculation over the summer, as he was very close to a €20m transfer to Fiorentina, but eventually moved from Sporting CP to Rennes on deadline day.
He is surprisingly on the bench, as Rennes seem to have adapted to a 3-5-2 formation to mirror Lazio’s tactical approach, with Flavien Tait the partner to Niang instead.
Lazio: Strakosha; Vavro, Acerbi, Bastos; Lazzari, Parolo, Cataldi, Berisha, Lulic; Caicedo, Immobile
Lazio bench: Proto, Luiz Felipe, Patric, Milinkovic-Savic, Luis Alberto, Jony, Adekanye
Rennes: Mendy; Da Silva, Gnagnon, Morel; Traore, Grenier, Martin, Camavinga, Doumbia; Tait, Niang
Rennes bench: Salin, Raphinha, Lea Siliki, Bourigeaud, Maouassa, Hunou, Gelin
Ref: Boiko (UKR)
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