Milan revamp in their must-win trip to Genoa, as Leo Duarte, Jack Bonaventura and Lucas Biglia step into the starting XI.
It kicks off at the Stadio Luigi Ferraris at 19.45 UK time (18.45 GMT).
You can follow the build-up and action as it happens and give your views on the LIVEBLOG.
This is a Last Chance Saloon for both tacticians, as Aurelio Andreazzoli and Marco Giampaolo are hanging by a thread after dismal starts to the season.
Milan have only six points, losing four of the opening six rounds, just one point clear of Genoa.
Their main problems have been in attack, scoring only two goals from open play, while Krzysztof Piatek has been struggling badly in recent months.
Perhaps being back at Marassi will help inspire the scoring touch that saw him net 19 goals in 21 competitive games for Genoa from August 2018 to January 2019, 13 in 19 Serie A appearances.
He is flanked by another ex-Genoa player, Suso, but it's not yet clear if Jack Bonaventura or Hakan Calhanoglu have the attacking role, as both are versatile.
The 30-year-old had knee ligament surgery practically a year ago and has not started a match since October 25 against Real Betis.
Bonaventura has made only one appearance since then, for 25 minutes in the 2-1 defeat to Torino on September 26.
Leo Duarte steps in for suspended Mateo Musacchio and Mattia Caldara is injured.
Ismael Bennacer is dropped in favour of Lucas Biglia, while there is still no room for Lucas Paqueta and even inventive Rafael Leao is benched after his solo goal against Fiorentina.
Calhanoglu, meanwhile, has featured in every Milan game in 2019 and started all seven this season.
Genoa are in dire straits too, with reports Andreazzoli is hanging by a thread.
He must do without injured Antonio Barreca, so Marko Pajac steps in, while Andrea Pinamonti partners Christian Kouame.
It’s a special game for ex-Milan defender Cristian Zapata, as the 33-year-old Colombian made 148 appearances for the Rossoneri.
Genoa have lost four of their last five Serie A meetings with Milan, drawing the other.
Milan need to avoid losing five of their opening seven Serie A matches, something they experienced only in 1938-39.
Genoa: Radu; Romero, C Zapata, Criscito; Ghiglione, Schone, Radovanovic, Lerager, Pajac; Kouame, Pinamonti
Genoa bench: Marchetti, Jandrei, Goldaniga, Sanabria, El Yamiq, Biraschi, Jagiello, Pandev, Cassata, Favilli, Ankersen, Saponara
Milan: G Donnarumma; Calabria, Duarte, Romagnoli, Theo Hernandez; Kessie, Biglia, Bonaventura; Suso, Piatek, Calhanoglu
Milan bench: Reina, A Donnarumma, Bennacer, Castillejo, Borini, Conti, Leao, Rebic, Krunic, Paqueta, Gabbia, Ricardo Rodriguez
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/