Juventus pick Paulo Dybala and Rodrigo Bentancur with Cristiano Ronaldo in their Champions League encounter with Joao Mario’s injury-hit Lokomotiv Moscow.
It kicks off in Turin at 20.00 UK time (19.00 GMT).
You can follow the build-up and action as it happens in that game and Manchester City-Atalanta on the LIVEBLOG.
The Bianconeri are still unbeaten in all competition this season, dropping points only in draws away to Atletico Madrid and Fiorentina.
Giorgio Chiellini, Douglas Costa, Aaron Ramsey and Mattia De Sciglio are still out injured, but Federico Bernardeschi and Gonzalo Higuain drop to the bench.
Dybala had already started against Inter, but Bentancur is moved to a new trequartista slot for the Uruguay international.
Juan Cuadrado is preferred to the not 100 per cent fit Danilo at right-back.
It’s a potential record for Cristiano Ronaldo, who has scored against 33 different clubs in the Champions League, on a par with Real Madrid legend Raul, but Lokomotiv Moscow would make it 34.
Lokomotiv Moscow only faced Juve before in the 1993 UEFA Cup, which was their first ever European match, but strangely 26 years ago the coach was the same man in charge today – 72-year-old Yuri Semin.
He has an injury crisis on his hands, missing Jefferson Farfan, Anton Miranchuk, Luka Djordjevic, Fedor Smolov, Rifat Zhemaletdinov and Maciej Rybus.
There are still some star names, such as Joao Mario on loan from Inter, Croatia legend Vedran Corluka and impressive Polish midfielder Grzegorz Krychowiak.
It’s also a familiar face in defence, as Benedikt Howedes spent one season at Juve on loan, although he only ever made three appearances due to a series of injury problems.
Eder is the only real option in attack, famously the man who scored the extra time goal for Portugal that decided Euro 2016.
Lokomotiv Moscow pulled a surprise in their opening group game, winning 2-1 away to Bayer Leverkusen, falling 2-0 at home to Atletico Madrid with second-half goals.
Juventus: Szczesny; Cuadrado, Bonucci, De Ligt, Alex Sandro; Khedira, Pjanic, Matuidi; Bentancur; Dybala, Cristiano Ronaldo
Juventus bench: Buffon, Danilo, Higuain, Rugani, Rabiot, Demiral, Bernardeschi
Lokomotiv Moscow: Guilherme; Ignatyev, Howedes, Corluka, Idowu; Murilo; Al Miranchuk, Barinov, Krychowiak, Joao Mario; Eder
Lokomotiv bench: Kochenkov, Zhivoglyadov, Kolomeytsev, Kverkvelia, Magkeev, Tugarev, Kulikov
Ref: Sidiropoulos (GRE)
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