Roma rely on Edin Dzeko, Javier Pastore and Nicolò Zaniolo in their Europa League trip to Borussia Monchengladbach, who move Marcus Thuram to centre-forward.
It kicks off at 20.00 GMT, follow all the build-up and action as it happens from this game and Lazio-Celtic on the LIVEBLOG.
These sides played out a hugely controversial 1-1 draw at the Olimpico a couple of weeks ago, decided by a last-gasp penalty awarded for non-existent handball, as it clearly struck Chris Smalling in the face.
There is no VAR in the Europa League group stage, so it was impossible to show the referee that he had made a massive mistake.
Roma remain top of the group and in a solid position to qualify, even through the injury crisis that has ruled out Davide Spinazzola, Lorenzo Pellegrini, Davide Zappacosta, Henrikh Mkhitaryan, Bryan Cristante and Nikola Kalinic.
Mert Cetin and Daniel Fuzato cannot contribute, as they are not on the UEFA list.
It means Gianluca Mancini is again re-routed to midfield, where he has been a revelation alongside Jordan Veretout, while Zaniolo, Pastore and Justin Kluivert support Dzeko, a centre-forward given no opportunity to rest.
Yet again, for reasons that are still unclear, Alessandro Florenzi is benched in favour this time of Davide Santon.
Borussia Monchengladbach are three points clear at the top of the Bundesliga table, but have injury problems of their own, missing Breel Embolo, Raffael, Keanan Bennetts, Tobias Sippel, Torben Musel and Fabian Johnson, while Alassane Plea is not fully fit.
They decide to therefore move attacking winger Marcus Thuram – son of ex-Juventus and Parma star Lilian – into a centre-forward position.
Lars Stindl came off the bench to convert the penalty at the Olimpico, but he is in the starting XI today after recovering from injury.
The only Italians who beat Gladbach on their own turf were Fiorentina in the 2016-17 Europa League Round of 32 and the referee that day was the same as this evening, Jesus Gil Manzano.
Serie A sides are unbeaten here since October 1975, followed by four draws and that Viola victory.
Borussia Monchengladbach: Sommer; Jantschke, Ginter, Elvedi; Lainer, Benes, Zakaria, Wendt; Neuhaus; Stindl, Thuram
Gladbach bench: Grun, Strobl, Kramer, Plea, Beyer, Hofmann, Bensebaini
Roma: Pau Lopez; Santon, Smalling, Fazio, Kolarov; Veretout, Mancini; Zaniolo, Pastore, Kluivert; Dzeko
Roma bench: Mirante, Juan Jesus, Perotti, Under, Florenzi, Diawara, Antonucci
Ref: Jesus Gil Manzano (ESP)
Watch Serie A live in the UK on Premier Sports for just £9.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/