Inter try to keep the pressure on Juventus with Romelu Lukaku and Lautaro Martinez, as troubled Inter rely on Andrea Belotti and Simone Verdi.
It kicks off at the Stadio Olimpico Grande Torino at 19.45 GMT.
Antonio Conte’s Nerazzurri have been performing above expectations, especially considering the injury crisis that continues to rule out Alexis Sanchez, Matteo Politano, Stefano Sensi, Kwadwo Asamoah and Roberto Gagliardini.
Danilo D’Ambrosio returns to the fold, but Lukaku and Lautaro Martinez remain the only real options upfront.
Torino finally ended a disastrous run of two points in six rounds by beating Brescia 4-0 just before the break for international duty.
Walter Mazzarri and President Urbano Cairo remain under pressure from unhappy fans, though, and currently sit in 11th place.
Iago Falque picked up yet another injury, joined on the sidelines by Lyanco, Diego Laxalt and Kevin Bonifazi.
Cristian Ansaldi returns from suspension to help support Verdi and Italy international Belotti, with Alex Berenguer dropped to the bench.
Inter have famously struggled against Torino, failing to win any of their last five Serie A meetings.
That includes two consecutive defeats in this stadium, but they haven’t lost three in a row away to Torino in Serie A since October 1977.
The Nerazzurri have also won all six away fixtures in the league this season.
Torino: Sirigu; Izzo, Nkoulou, Bremer; De Silvestri, Baselli, Lukic, Meite, Ansaldi; Verdi, Belotti
Torino bench: Ujkani, Rosati, Zaza, Edera, Berenguer, Djidji, Aina, Rincon
Inter: Handanovic; Godin, De Vrij, Skriniar; D’Ambrosio, Vecino, Brozovic, Barella, Biraghi; R Lukaku, Lautaro Martinez
Inter bench: Padelli, Berni, Ranocchia, Lazaro, Borja Valero, Dimarco, Esposito, Agoume, Fonseca, Candreva, Bastoni
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