Inter aim to set a new all-time club record best start to the Serie A season, as Valentino Lazaro steps in against Andrea Petagna’s SPAL.
It kicks off at San Siro at 14.00 GMT.
No Nerazzurri team has ever begun a top flight campaign winning 12 of their 14 games, so this could be a club record start for Antonio Conte’s men.
The history looks promising, as SPAL have never won a Serie A visit to Inter, managing just two draws in 18 attempts, the most recent in February 1963.
The last SPAL player to score in a Serie A match away to Inter was Fabio Capello in October 1966. The Spallini coach that day was Francesco Petagna, grandfather of current striker Andrea.
Stefano Sensi, Nicolò Barella and Alexis Sanchez are still out of action, with Kwadwo Asamoah only just shaking off a muscular issue after three weeks out.
Following the midweek Champions League victory away to Slavia Prague, Conte rotates the squad slightly, with Danilo D’Ambrosio stepping in to the defence, Valentino Lazaro moved over to the left, plus Roberto Gagliardini returning in the centre.
Once again, Lautaro Martinez and Romelu Lukaku lead from the front.
SPAL are without suspended Simone Missiroli, while Federico Di Francesco, Marco D’Alessandro and Mohamed Fares are long-term injury absentees.
Gabriel Strefezza not only recovers to be in the squad, but is in the starting XI as support for Petagna.
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar; Candreva, Vecino, Brozovic, Gagliardini, Lazaro; Lukaku, Lautaro Martinez
SPAL: Berisha; Igor, Vicari, Tomovic; Valoti, Murgia, Valdifiori, Kurtic, Reca; Strefezza, Petagna
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