Cagliari are without the suspended Fabrizio Cacciatore and Robin Olsen against Sampdoria, who have similar issues at the back.
Cacciatore and Olsen were sent off during Cagliari’s 2-2 draw with Lecce last Monday, so Rafael and Paolo Farago come into the starting XI tonight.
Elsewhere, Nahitan Nandez makes way for Lucas Castro in the middle of the park and Radja Nainggolan plays for the first time since being crowned Serie A’s Player of the Month for November.
Samp, meanwhile, are without the injured Bartosz Bereszynski and Fabio Depaoli, so midfielder Morten Thorsby fills in at right-back.
Andrea Bertolacci is also missing for the Blucerchiati so former Leeds United youngster Ronaldo Vieira is brought into midfield.
Tonight’s match pits together two of Serie A’s most in-form sides, with both unbeaten in their last four fixtures.
Cagliari: Rafael, Farago, Pisacane, Klavan, Pellegrini; Castro, Cigarini, Rog; Nainggolan; Joao Pedro, Simeone
Subs: Aresti, Ciocci, Lykogiannis, Mattiello, Pinna, Walukiewicz, Deiola, Ionita, Nandez, Oliva, Cerri, Ragatzu
Sampdoria: Audero; Thorsby, Colley, Ferrari, Murru; Ramirez, Ekdal, Vieira, Jankto; Gabbiadini, Quagliarella
Subs: Seculin, Falcone, Augello, Chabot, Linetty, Rigoni, Caprari, Regini, Maroni, Murillo, Leris
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