Paulo Dybala is dropped to the Juventus bench in favour of Federico Bernardeschi, while Napoli pick Arkadiusz Milik, Lorenzo Insigne and Elseid Hysaj.
It kicks off at the Stadio San Paolo at 19.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
Paulo Dybala is dropped to the Juventus bench in favour of Federico Bernardeschi, while Napoli pick Arkadiusz Milik, Lorenzo Insigne and Elseid Hysaj.
It kicks off at the Stadio San Paolo at 19.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
Coach Massimiliano Allegri confirmed in his Press conference that Cristiano Ronaldo will start after recovering from a knock to the ankle, while he had to choose between Emre Can and Rodrigo Bentancur in midfield, then Dybala or Bernardeschi in a linking role.
Emre Can gets the nod, with Miralem Pjanic now recovered from a bout of flu.
In attack, Dybala is benched again in favour of Bernardeschi, who can shift to make it a 4-3-3, 4-4-2 or a 4-3-1-2 formation, as he is so tactically versatile.
Douglas Costa, Sami Khedira and Juan Cuadrado are still out of action.
Napoli have Mario Rui back from his injury lay-off, but the Portugal international is only on the bench.
There had been a decision to make between Elseid Hysaj and Faouzi Ghoulam, with the Albanian considered in better physical condition.
Carlo Ancelotti picks on form Kevin Malcuit at right-back, with Raul Albiol still injured and Nikola Maksimovic joining Kalidou Koulibaly in the centre.
The only other choice was in attack, as Insigne returns after missing the 4-0 win at Parma through suspension, with Arek Milik picked rather than Dries Mertens.
Napoli (official): Meret; Malcuit, Maksimovic, Koulibaly, Hysaj; Callejon, Allan, Fabian, Zielinski; Milik, Insigne
Napoli bench: Ospina, Karnezis, Chiriches, Ghoulam, Luperto, Mario Rui, Diawara, Verdi, Ounas, Mertens, Younes
Juventus (official): Szczesny; Cancelo, Bonucci, Chiellini, Alex Sandro; Emre Can, Pjanic, Matuidi; Bernardeschi, Mandzukic, Cristiano Ronaldo
Juventus bench: Perin, Pinsoglio, Rugani, Barzagli, Caceres, Spinazzola, De Sciglio, Bentancur, Dybala, Kean