Hakan Calhanoglu returns with Ante Rebic and Zlatan Ibrahimovic, as Milan continue their pursuit of European football against Federico Chiesa’s Fiorentina.
It kicks off at 19.45 GMT at the Stadio Franchi in Florence.
This is an emotional return to the city for Stefano Pioli, who was a beloved coach by the Viola and their fans for steering them through the tragic loss of Davide Astori.
He has transformed Milan’s season since replacing Marco Giampaolo, taking them up to joint sixth with Parma and Hellas Verona.
Much of that has been thanks to a change of system with January signing Ibrahimovic supported by Rebic, Samu Castillejo and Calhanoglu.
The Turkey international was injured last week and replaced by Lucas Paqueta, but he returns to that trequartista role.
Rade Krunic, Simon Kjaer and Lucas Biglia are injured, so Matteo Gabbia is chosen at centre-back.
This is a special game for Rebic too, as he made his Serie A debut for Fiorentina and they still have a percentage of his next transfer fee.
Fiorentina are coming off a 5-1 thrashing of Sampdoria at Marassi, with Chiesa and Dusan Vlahovic scoring a brace each.
They are therefore confirmed together, leaving former Milan youth team product Patrick Cutrone on the bench to begin with.
Franck Ribery and Christian Kouame are long-term injury absentees, with Milan Badelj suspended.
Milan have lost only two of their last 13 Serie A trips to Florence, winning six and drawing five.
Fiorentina: Dragowski; Milenkovic, Pezzella, Caceres; Lirola, Duncan, Pulgar, Castrovilli, Dalbert; Vlahovic, Chiesa
Fiorentina bench: Terracciano, Brancolini, Igor, Sottil, Ceccherini, Ghezzal, Agudelo, Venuti, Benassi, Dalle Mura, Cutrone, Terzic
Milan: G Donnarumma; Conti, Gabbia, Romagnoli, Theo Hernandez; Kessie, Bennacer; Castillejo, Calhanoglu, Rebic; Ibrahimovic
Milan bench: Begovic, A Donnarumma, Calabria, Bonaventura, Leao, Musacchio, Paqueta, Saelemaekers, Laxalt, Brescianini, Maldini
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