Daniel Siebert will lead Inter and Ludogorets in an empty San Siro on Thursday, whilst Josè María Sánchez Martínez has been given KAA Gent-Roma.
UEFA have announced the referees for the return legs of the Europa League round of 32 and the experienced German Siebert will be given the match at San Siro.
The game will be played behind closed doors and the 35-year-old will lead the Nerazzurri for the first time.
Sánchez Martínez has been handed the appointment in Belgium, as Roma lead 1-0 ahead of the return leg and the La Liga referee has already overseen two Europa League matches this term.
Referees for the return legs of the Europa League round of 32
Gent-Roma:Sanchez Martinez (Spain) – VAR: Del Cerro Grande (Spain)
Inter-Ludogorets:Siebert (Germany) – VAR: Dankert (Germany)
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