Roma have Henrikh Mkhitaryan, Carles Perez and Justin Kluivert supporting Edin Dzeko, with a 1-0 lead to protect in the Europa League with KAA Gent.
It kicks off in Belgium at 17.55 GMT and the first leg ended 1-0 for the Giallorossi at the Stadio Olimpico.
You can follow all the build-up and action as it happens from this game and Inter-Ludogrets on the LIVEBLOG.
Roma have Henrikh Mkhitaryan, Carles Perez and Justin Kluivert supporting Edin Dzeko, with a 1-0 lead to protect in the Europa League with KAA Gent.
It kicks off in Belgium at 17.55 GMT and the first leg ended 1-0 for the Giallorossi at the Stadio Olimpico.
Gent were narrowly beaten 1-0 at the Olimpico by an early Carles Perez strike and the January signing also starts in attack this evening.
He is in the group with Mkhitaryan, Kluivert and centre-forward Dzeko, with Lorenzo Pellegrini, Javier Pastore, Amadou Diawara, Mert Cetin and Davide Zappacosta injured.
Diego Perotti is in the stands due to a stomach bug, but Gianluca Mancini steps back into defence after a brief foray in midfield to fill the gaps.
Gent must do without injured forward Roman Yaremchuk, but Laurent Depoitre will hope to do better after a rusty performance in Rome, having just returned from several weeks out of action.
The real one to watch is Jonathan David, the 20-year-old Canada international fresh from a hat-trick at the weekend.
Gent: Kaminski; Castro-Montes, Plastun, Ngadeu-Ngadjui, Mohammadi; Kums, Owusu, Odjidja; Bezus; Depoitre, David
Gent bench: Coosemans, Chakvetadze, Niangbo, Kvilitaia, Marreh, Lustig, Godeau
Roma: Pau Lopez; Spinazzola, Mancini, Smalling, Kolarov; Cristante, Veretout; Perez, Mkhitaryan, Kluivert; Dzeko
Roma bench: Fuzato, Villar, Cetin, Under, Santon, Kalinic, Fazio
Ref: Maria Sanchez (ESP)