Brescia look almost doomed to relegation and are still missing Mario Balotelli, but Genoa are also in the bottom three and transform their line-up for this six-pointer.
It kicks off at 16.15 UK time (15.15 GMT), you can follow the build-up and action as it happens from this game, Cagliari-Torino and Lazio-Fiorentina on the LIVEBLOG.
The Rondinelle have only won four games this season and all of them were under coach Eugenio Corini, who was fired, rehired and dismissed again.
Diego Lopez did resume after the lockdown with a surprise 1-1 draw away to 10-man Fiorentina, but is still missing injured Dimitri Bisoli, Jhon Chancellor and Andrea Cistana, leaving very few options in defence.
Balotelli is back in training, but a long way off fitness, so Ernesto Torregrossa partners Alfredo Donnarumma.
Genoa are in the bottom four following their 4-1 home defeat to Parma, a disastrous game because Domenico Criscito saw his penalty saved and then limped off with an injury.
The captain is out of action and at risk for the next match with Juventus, joining Ivan Radovanovic on the treatment table.
Coach Davide Nicola rotates his squad, with Iago Falque, Mattia Destro and Andrea Pinamonti promoted to the starting XI.
Brescia: Joronen; Sabelli, Papetti, Mateju, Semprini; Dessena, Tonali, Bjarnason; Zmrhal; Torregrossa, Donnarumma
Genoa: Perin; Birasghi, Soumaoro, C Zapata, Romero; Barreca, Behrami, Sturaro, Iago Falque; Destro, Pinamonti
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