Lazio must win to keep their Scudetto hopes alive, but have injury problems as they host struggling Fiorentina, who must do without Federico Chiesa.
It kicks off at the Stadio Olimpico at 20.45 UK time (19.45 GMT).
The Biancocelesti saw their Scudetto hopes badly hit by a 3-2 defeat to Atalanta on their first game back, having taken a 2-0 lead in Bergamo.
Juventus beat Lecce 4-0 last night, opening up a temporary seven-point lead at the top of the table.
Therefore, Simone Inzaghi’s men simply have to win tonight, but Lucas Leiva, Senad Lulic, Luiz Felipe and Bobby Adekanye are still out of action.
Danilo Cataldi and Adam Marusic are not 100 per cent fit, so Marco Parolo steps in, while Felipe Caicedo gets the nod with Ciro Immobile upfront.
Fiorentina were held to a disappointing 1-1 draw by Brescia and losing their temper proved even more damaging, because Martin Caceres, Federico Chiesa and coach Beppe Iachini are all suspended.
Christian Kouame is a long-term injury absentee, so the lack of Chiesa forces a change of tactics.
The Viola are more of a 3-5-2 this evening, with Franck Ribery and Patrick Cutrone forming an all-new partnership, resting Dusan Vlahovic.
Lazio: Strakosha; Patric, Acerbi, Bastos; Lazzari, Milinkovic-Savic, Parolo, Luis Alberto, Jony; Caicedo, Immobile
Fiorentina: Dragowski; Milenkovic, Pezzella, Ceccherini; Lirola, Ghezzal, Badelj, Castrovilli, Dalbert; Ribery, Cutrone
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