Ciro Immobile and Felipe Caicedo return to the Lazio attack at the Via del Mare, facing a Lecce in desperate need of three points.
Serie A Week 36 opens with Lecce-Lazio at 18:30 GMT in Puglia, before Milan host Juventus in the late kick-off.
Lecce sit two points behind safety and could do with an upset against a crumbling Biancocelesti, who in recent weeks have fallen seven points behind league leaders Juventus in the title race.
But Fabio Liverani struggles with injuries and suspensions ahead of the big game, with Panagiotis Tachtsidis out with a one-match ban.
Gianluca Lapadula and Luca Rossettini are also missing and force the coach to experiment. Jacopo Petriccione is set for a role in the middle.
Khouma Babacar and Diego Farias should lead the line against Simone Inzaghi’s men, who arrive in need of a positive experience.
The Aquile have lost two in three but will have Immobile and Caicedo back from suspensions, as the two forwards left Lazio toothless against a high-flying Milan last weekend.
Luiz Felipe is also back in the squad but Inzaghi crosses his fingers to recover Manuel Lazzari in time but looks set to cope without the full-back.
Djavan Anderson could therefore start at right and Jony at left, whilst Sergej Milinkovic-Savic should take place in the middle – most likely with Lucas Leiva and Luis Alberto.
Lecce (probable): Gabriel; Rispoli, Lucioni, Paz, Donati; Barak, Petriccione, Mancosu; Saponara; Babacar, Farias
Lazio (probable): Strakosha; Patric, Acerbi, Radu; Djavan Anderson, Milinkovic, Leiva, Luis Alberto, Jony; Caicedo, Immobile
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