Genoa will bring Lasse Schone back into the fold against Napoli, who are without the suspended Kalidou Koulibaly.
The match kicks off at 18:30 UK time – click here for a preview.
Schone served a yellow-card ban for the 2-2 draw with Udinese, but he should make a swift return to central midfield.
However, Juventus loanee Cristian Romero is injured so Adama Soumaoro should partner Edoardo Goldaniga and Andrea Masiello at the back.
Napoli, meanwhile, will go with Nikola Maksimovic and Kostas Manolas as centre-backs, given Koulibaly is banned for one match.
Elsewhere, Piotr Zielinski and the similarly-suspended Diego Demme should make way for midfielders Stanislav Lobotka and Eljif Elmas.
Finally, Dries Mertens and probably Matteo Politano will join captain Lorenzo Insigne in a front three.
Genoa (probable): Perin; Goldaniga, Soumaoro, Masiello; Biraschi, Behrami, Schone, Sturaro, Barreca; Pinamonti, Sanabria
Napoli (probable): Meret; Hysaj, Manolas, Maksimovic, Mario Rui; Fabian, Lobotka, Elmas; Politano, Mertens, Insigne
Watch Serie A live in the UK on Premier Sports for just £9.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://www.premiersports.com/subscribenow