Ciro Immobile is out to break the all-time Serie A scoring record and potentially take second place for Lazio, while Napoli have Dries Mertens and Jose Callejon back.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio San Paolo.
Lazio could still take second place if they win here, while Atalanta and Inter draw in their head-to-head in Bergamo.
Immobile already knows he is Capocannoniere of Serie A and also the European Golden Shoe winner, as Cristiano Ronaldo was the only one able to catch him and is not even in the Juventus squad to face Roma this evening.
He is on 35 goals and needs just one to equal the all-time Serie A scoring record for a single season, set in this very stadium by Gonzalo Higuain’s hat-trick for Napoli against Frosinone in May 2016.
Lucas Leiva, Felipe Caicedo, Senad Lulic and Stefan Radu are injured, so Joaquin Correa partners Immobile with Luis Alberto and Sergej Milinkovic-Savic in midfield.
Napoli miss Alex Meret, as the goalkeeper pulled out this afternoon with a stomach bug, so David Ospina takes the gloves.
Callejon plays his final match at the Stadio San Paolo, as his contract is due to expire and a renewal now seems highly improbable, completing the traditional trident attack with Mertens and Lorenzo Insigne.
Kostas Manolas is surprisingly back in the starting XI after cracking a couple of ribs.
Lazio: Strakosha; Patric, Luiz Felipe, Acerbi; Lazzari, Milinkovic-Savic, Parolo, Luis Alberto, Marusic; Correa, Immobile
Napoli: Ospina; Di Lorenzo, Manolas, Koulibaly, Mario Rui; Fabian Ruiz, Lobotka, Zielinski; Callejon, Mertens, Insigne
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