Napoli could throw Tiemoue Bakayoko in from the start, while Victor Osimhen depends on the tactical choices against Atalanta.
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The Partenopei are still missing Piotr Zielinski and Eljif Elmas after their COVID-19 tests, while Arkadiusz Milik has been left out of the squad.
Lorenzo Insigne is also injured, making it more likely Gennaro Gattuso will risk the 4-2-3-1 formation rather than his trusted 4-3-3.
This would allow Osimhen to lead the attack with support from Dries Mertens, Matteo Politano and Hirving Lozano.
There are reports Bakayoko could be given his Napoli debut from the start, reuniting with his former Milan coach Gattuso on loan from Chelsea.
Atalanta have a 100 per cent record so far this season and scored four goals in each of those three games.
Mattia Caldara is out for three months following knee surgery, with goalkeepers Pierluigi Gollini and Marco Carnesecchi also sidelined.
Josip Ilicic is back in the squad for the first time since July 11, but it is improbable he’ll be played from the start after such a long period out with mental health concerns.
Duvan Zapata, Luis Muriel and Papu Gomez are tired from international duty, so Ruslan Malinovskyi and Sam Lammers are options to step in.
Napoli (4-2-3-1): Ospina; Di Lorenzo, Koulibaly, Manolas, Hysaj; Bakayoko, Fabian Ruiz; Politano, Mertens, Lozano; Osimhen
Atalanta (3-4-2-1): Sportiello; Toloi, Palomino, Djimsiti; Hateboer, De Roon, Freuler, Gosens; Gomez, Malinovskyi; Duvan Zapata
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