Atalanta need to get back on track in Serie A, giving Josip Ilicic and Sam Lammers the chance to shine with Papu Gomez against Sampdoria.
It kicks off at 14.00 UK time (13.00 GMT) at the Gewiss Stadium in Bergamo.
La Dea are still smarting after last week’s 4-1 defeat to Napoli ended their perfect record, although the 4-0 Champions League win away to Midtjylland helped to make up for it.
Due to the long journey to Denmark and playing in the driving rain, coach Gian Piero Gasperini rotates his squad by changing seven of the starting XI, giving Ilicic and Lammers starts upfront with the irreplaceable Papu Gomez.
Mattia Caldara, Pierluigi Gollini and Marco Carnesecchi are still out of action.
Sampdoria caused an upset last week by beating Lazio 3-0 and hope to catch another Serie A big club off guard between European fixtures.
Manolo Gabbiadini is not 100 per cent fit, so Gaston Ramirez again supports Fabio Quagliarella, with Keita Balde Diao on the bench.
Atalanta: Sportiello; Sutalo, Palomino, Djimsiti; Depaoli, Pasalic, De Roon, Mojica; Gomez; Ilicic, Lammers
Sampdoria: Audero; Bereszynski, Tonelli, Yoshida, Augello; Jankto, Thorsby, Ekdal, Damsgaard; Ramirez, Quagliarella