The pressure is growing on Inter and they again look to Christian Eriksen, Romelu Lukaku and Lautaro Martinez against a Genoa side recovering from their COVID outbreak.
It kicks off at 17.00 UK time (16.00 GMT), you can follow all the build-up and action as it happens on the LIVEBLOG.
Antonio Conte is feeling the tension after a series of disappointing results, drawing with Lazio and Borussia Monchengladbach, losing the Derby della Madonnina to Milan.
Choices are also limited due to injuries and COVID-19, ruling out Ashley Young, Milan Skriniar, Roberto Gagliardini, Ionut Radu and Matias Vecino.
However, Hakimi is on the bench after he tested positive for COVID-19 during the UEFA test on Wednesday, forcing him to miss the Borussia Monchengladbach draw, but was then negative on his next two tests performed by Inter and Serie A.
It’s believed the UEFA one was a ‘false positive’ test and he was unduly forced to miss the match.
It means Eriksen is given a second consecutive start behind Lautaro Martinez and Romelu Lukaku, as Alexis Sanchez is carrying a knock.
Matteo Darmian impressed in the Champions League on his debut and again takes the right flank.
Andrea Ranocchia is an intriguing choice at centre-back, as he was on the verge of joining Genoa in the final days of the transfer window, but Inter decided to keep him after Diego Godin's move to Cagliari.
Genoa are recovering from their own COVID-19 outbreak, as only Stefano Sturaro and Inter-owned Darian Males are still out of action.
Former Inter striker Goran Pandev is partnered by Marko Pjaca, with veterans Milan Badelj and Valon Behrami in midfield.
Genoa: Perin; Bani, C Zapata, Goldaniga; Ghiglione, Behrami, Badelj, Rovella, Czyborra; Pandev, Pjaca
Genoa bench: Marchetti, Paleari, Biraschi, Zajc, Radovanovic, Destro, Melegoni, Masiello, Shomurodov, Parigini, Pellegrini, Dumbravanu
Inter: Handanovic; D’Ambrosio, Ranocchia, Bastoni; Darmian, Vidal, Brozovic, Perisic; Eriksen; R Lukaku, Lautaro Martinez
Inter bench: Padelli, Stankovic, Hakimi, De Vrij, Kolarov, Barella, Moretti, Nainggolan, Vezzoni, Carboni, Satriano, Pinamonti