Napoli look to Andrea Petagna, Lorenzo Insigne and a new Stanislav Lobotka role in their Europa League trip to Real Sociedad.
It kicks off at 20.00 GMT, follow the build-up and action as it happens from this game, Milan-Sparta Prague and Roma-CSKA Sofia on the LIVEBLOG.
The Partenopei were torn between the need to rotate the squad and also get back on track in Europe, having suffered a shock 1-0 opening home defeat to AZ Alkmaar.
David Ospina returns in goal, but Dries Mertens and Victor Osimhen are rested, with Matteo Politano and Andrea Petagna coming in.
The biggest change is Lobotka pushed into a more advanced role behind the strikers, leaving Tiemoue Bakayoko and Diego Demme in midfield.
It had been reported that Fabian Ruiz would take this new position, but Lobotka was eventually given the nod.
Real Sociedad start David Silva, who had been on the verge of joining Lazio as a free agent this summer, in support of Alexander Isak, Cristian Portugues and Mikel Oyarzabal.
Asier Illaramendi and Joseba Zaldua are out of action, while Adnan Januzaj is only fit for a spot on the bench.
Real Sociedad: Remiro; Gorosabel, Elustondo, Le Normand, Monreal; Merino, Guevara, David Silva; Portugues, Isak, Oyarzabal
Real Sociedad bench: Moya, Aihen, Sagnan, Arambarri, Guridi, Zubimendi, Willian Jose, Januzaj, Merquelanz, Barrentxea, Bautista, Lopez
Napoli: Ospina; Hysaj, Maksimovic, Koulibaly, Mario Rui; Demme, Bakayoko; Politano, Lobotka, Insigne; Petagna
Napoli bench: Meret, Elmas, Fabian Ruiz, Osimhen, Lozano, Mertens, Contini, Zielinski, Di Lorenzo, Ghoulam, Rrahmani, Manolas
Ref: Pawson (ENG)