Cristiano Ronaldo is back, but only on the bench, while Federico Chiesa, Alvaro Morata and Paulo Dybala start for Juventus against plucky Spezia.
It kicks off at 14.00 GMT, you can follow all the build-up and action from today’s six Serie A games on the LIVEBLOG.
Andrea Pirlo is struggling in his debut season so far, held to draws by Crotone and Verona, then soundly beaten 2-0 by Barcelona in the Champions League midweek.
Ronaldo returns after three weeks out with COVID-19, but is only on the bench to begin with, as Chiesa is back from suspension in support of Morata and misfiring Dybala.
Giorgio Chiellini, Alex Sandro and Matthijs de Ligt are still out injured, Aaron Ramsey only fit for the bench and Dejan Kulusevski shelved for a more solid 3-5-2 formation.
This is a special day for Juventus, as the club was first founded 123 years ago today.
Spezia are in their first ever Serie A season, but have shown they take an attacking approach to any opponent and also tend to fumble leads, such as last week’s 2-0 at Parma ending 2-2.
Coach Vincenzo Italiano has injury problems to contend with, including Jacopo Sala, Andrej Galabinov, Federico Mattiello, Jeroen Zoet and Gennaro Acampora.
Riccardo Marchizza returns to the bench with Inter-owned Lucien Agoume, while Daniele Verde is promoted to the front line with M’Bala Nzola and Diego Farias rather than Emmanuel Gyasi.
Spezia: Provedel; Ferrer, Chabot, Terzi, S Bastoni; Bartolomei, Ricci, Pobega; Verde, Nzola, Farias
Juventus: Buffon; Demiral, Bonucci, Danilo; Cuadrado, Bentancur, Arthur, McKennie, Chiesa; Morata, Dybala