Roma rely on Henrikh Mkhitaryan, Borja Mayoral and Gonzalo Villar in the Europa League against Mario Rondon’s joint leaders CFR Cluj.
It kicks off at 17.55 GMT at the Stadio Olimpico in Rome.
The Giallorossi are currently joint top of Group A with Cluj on four points, but the Romanians are in disarray after coach Dan Petrescu announced this would be his last match in charge.
Paulo Fonseca rotates his squad, sending the likes of Edin Dzeko, Chris Smalling and Pedro to the bench, with Gianluca Mancini suspended.
He starts Pau Lopez in goal, with Federico Fazio in defence, Villar, Mkhitaryan and Borja Mayoral upfront.
Cluj’s most famous player is probably 34-year-old Venezuela international Mario Rondon, who scored in each of his last two Europa League appearances.
There are only six players available on the Cluj bench.
Roma: Pau Lopez; Fazio, Ibanez, Kumbulla; Bruno Peres, Veretout, Cristante, Spinazzola; Villar, Mkhitaryan; Borja Mayoral
Roma bench: Boer, Mirante, Karsdorp, Juan Jesus, Smalling, Pellegrini, Dzeko, Pedro, Zalewski, Milanese, Tripi
Cluj: Balgradean; Susic, Manea, Ciobotariu, Camora; Hoban; Deac, Itu, Dokovic; Rondon, Debeljuh
Cluj bench: Sandomierski, Paun, Pereira, Latovlevici, Joca, Carnat
Ref: Jug (SVN)