Cesare Prandelli makes his comeback on the Fiorentina bench and switches tactics to 4-2-3-1, relying on Franck Ribery against a revamped Benevento.
It kicks off at the Stadio Franchi at 11.30 GMT.
This is a return for the Viola coach, who replaced sacked Beppe Iachini and had already been a fan favourite from 2005-10.
He had been expected to ease the team away from the 3-5-2, but instead Prandelli goes straight in with a 4-2-3-1 formation, using Christian Kouame, Jack Bonaventura and Ribery as support for Dusan Vlahovic.
However, Bonaventura pulled out during the warm-up and was replaced by Alfred Duncan, presumably moving Gaetano Castrovilli into the more advanced role.
Although Jose Callejon has recovered from COVID-19, he’s not 100 per cent fit and only on the bench.
Benevento have been struggling since their promotion from Serie B and coach Pippo Inzaghi is forced to do without midfielder Bryan Dabo, who returned from international duty with Coronavirus.
Gianluca Caprari is still suspended, but it’s all change in attack, with Gianluca Lapadula and Roberto Insigne benched in favour of Riccardo Improta and Gabriele Moncini, giving Artur Ionita a more advanced role.
Fiorentina: Dragowski; Milenkovic, Pezzella, Igor, Biraghi; Amrabat, Duncan; Kouame, Castrovilli, Ribery; Vlahovic
Benevento: Montipò; Letizia, Caldirola, Glik, Barba; Schiattarella, Hetemaj; Improta, Sau, Ionita; Moncini